李艳华,东北农业大学二级教授、博士生导师,东农学术英才、动物药学学科带头人。现为国家生猪产业技术体系岗位科学家、中关村中兽医药产业技术创新战略联盟副理事长、中国畜牧兽医学会兽医药理与毒理学分会常务理事;主要研究方向为病原微生物耐药性的控制及兽药研发,先后主持国家及省市项目26项、发表学术论文128篇,其中SCI31篇、EI 2篇。获得“国家科学技术进步奖二等奖”1项、“黑龙江省科学技术奖(自然类)和(发明类)一等奖”各1项、“黑龙江省科学技术奖(发明类)二等奖”1项、黑龙江省青年科技奖、哈尔滨市青年科技奖,授权发明专利10项。主编农业部“十二五”规划教材1部、学术专著1部。
一、近五年项目
1.丁香叶干预2 型猪链球菌生物被膜形成的有效成分及其对cps基因簇调控研究/国家自然科学基金面上项目/2015.01.01-2018.12.31/84万/主持
2.基于IGPD靶点探讨芦丁干预奶牛乳腺炎木糖葡萄球菌生物被膜形成的作用机制/国家自然科学基金面上项目/2018.01.01-2021.12.31/60万/主持
3.国家生猪产业技术体系传统中兽医防治国家现代生猪产业技术体系岗位体系/2017.01.01-2020.12.31/280万/主持
4.抗猪链球菌病复方药物的研制/国家重点研发计划/2015.01.01-2019.12.31/50万/主持
5.部分革兰氏阳性菌生物被膜形成及多重耐药的机制研究及耐药抑制剂的确证/国家重点研发计划/2018.06.01-2020.12.31/36万/主持
6.没食子酸靶向半胱氨酸生物合成途径逆转猪链球菌磺胺嘧啶耐药性的研究郭晋安自然基金面上项目/2021.01-2024.12/58万/主持
二、近五年获奖
1.2020/国家科学技术奖/奶牛高发病防治系列新兽药创制与应用/二等奖
2.2017/黑龙江省畜牧科学技术奖自然科学类/民猪资源特性及其遗传机制/一等奖
3.2018/第七届全国兽医专业学位研究生优秀硕士学位论文/治疗奶牛乳房炎香连溶液配方的筛选及其药效学和安全性评价/优秀论文
4.2015/黑龙江省青年科技奖/第十二届黑龙江省青年科技奖/青年科技奖
三、近五年发表论文
1.Comparative proteomic analysis reveals drug resistance of Staphylococcus xylosus ATCC700404 under tylosin stress/BMC Veterinary Research(2019) 15:224/通讯作者
2.Antiviral Strategies of Chinese Herbal Medicine Against PRRSV Infection/Frontiers in Microbiology(2020)11:1756/通讯作者
3.Analysis of multidrug resistance in Streptococcus suis ATCC 700794 under tylosin stress/Virulence 2019, 10(1): 58-67/通讯作者
4.Chitosan Grafted With beta-Cyclodextrin: Synthesis, Characterization, Antimicrobial Activity, and Role as Absorbefacient and Solubilizer/Frontiers in Chemistry(2019)6:657/通讯作者
5.Discovery of Potential Anti-infective Therapy Targeting Glutamine Synthetase in Staphylococcus xylosus/Frontiers in Chemistry2019, 7: 381/通讯作者
6.Transcriptomic analysis reveals flavonoid biosynthesis of Syringa oblata Lindl. in response to different light intensityBMC Plant Biology(2019)19:487/通讯作者
7.In vitro activity and in vivo efficacy of Isoliquiritigenin against Staphylococcus xylosus ATCC 700404 by IGPD Target/PLOS ONE/通讯作者
8.Optimizating of Processing of Syringa oblata Lindl. By Response Surface Methodology and its Effect on Staphylococcus xylosus Biofilm/RSC Advances/通讯作者
9.1-Hydroxyanthraquinone exhibited antibacterial activity by regulating glutamine synthetase of Staphylococcus xylosus as a virulence factor/Biomedicine & Pharmacotherapy/通讯作者
10.Azithromycin Inhibits Biofilm Formation by Staphylococcus xylosus and Affects Histidine Biosynthesis PathwayFrontiers in Pharmacology(2018)9:543/通讯作者
11.Spectrum-effect Relationships between the Bioactive Ingredient of Syringa oblata Lindl. Leaves and its Role in Inhibiting the Biofilm Formation of Streptococcus suis/Frontiers in Pharmacology/(2018)9:570/通讯作者
12.The Influence of Shuttle-Shape Emodin Nanoparticles on the Streptococcus suis Biofilm/Frontiers in Pharmacology/(2018)9:227/通讯作者
13.Histidine Metabolism and IGPD Play a Key Role in Cefquinome Inhibiting Biofilm Formation of Staphylococcus xylosusFrontiers in Microbiology/(2018)9:665/通讯作者
14.Inhibition of Streptococcus suis Adhesion and Biofilm Formationin Vitroby Water Extracts of Rhizoma CoptidisFrontiers in Pharmacology/(2018)9:371/第一作者
15.Dissolution and oral bioavailability enhancement of praziquantel by solid dispersions/Drug Deliv Transl Res/通讯作者
16.Syringa oblata Lindl.Aqueous Extract Is a Potential Biofilm Inhibitor in S. suis /Frontiers in Pharmacology/(2017)8:26/通讯作者
17.Rutin Inhibits Streptococcus suis Biofilm Formation by Affecting CPS Biosynthesis/Frontiers in Pharmacology(2017)8:379/通讯作者
18.Sub-Minimum Inhibitory Concentrations of Rhubarb Water Extracts Inhibit Streptococcus suis Biofilm Formation/Frontiers in Pharmacology/(2017)8:425/通讯作者
19.Comparative Proteomic Analysis Provides insight into the Key Proteins as Possible Targets Involved in Aspirin Inhibiting Biofilm Formation of Staphylococcus xylosus/Frontiers in Pharmacology/(2017)8:543/通讯作者
20.Experimental Evaluation of the Transport Mechanisms of PoIFN-α in Caco-2 CellsFrontiers in Pharmacology/(2017)8:781/通讯作者
21.Homology Modeling and Virtual Screening to Discover Potent Inhibitors Targeting the ImidazoleGlycerophosphate Dehydratase Protein in Staphylococcus xylosus/Frontiers in Chemistry/(2017)5:98/通讯作者
22.Sub-MIC Tylosin Inhibits Streptococcus suis Biofilm Formation and Results in Differential Protein Expression/Frontiers in Microbiology/(2016)7:384/通讯作者
23.Sub-MICs of Azithromycin Decrease Biofilm Formation of Streptococcus suis and Increase Capsular Polysaccharide Content of S. suis/Frontiers in Microbiology/(2016)7:1659通讯作者
四、近五年荣誉称号
1.2020.1-至今/中关村中兽医药战略产业联盟/副理事长
2.2017.6-至今/农业农村部/国家生猪产业技术体系岗位科学家
3.2017.6-2022.7/农业农村部/兽药评审专家
4.2016.5-2019.6/现代生物兽药产业技术创新联盟/专家委员会资深专家
5.2011.11-2019.11/中国畜牧兽医学会兽医药理与毒理学分会/常务理事
6.2011.8-2016.12/黑龙江省畜牧兽医学会/常务理事
7.2014.6-现在/黑龙江省兽药产业联盟/顾问团专家
五、近五年获得授权发明专利
1.同时测定动物血浆中林可霉素和庆大霉素的液质联用方法ZL201710715124,1发明专利2020.03
2.大黄酸在制备抑制木糖葡萄球菌生物被膜药物中的用途ZL201410494065.62017.8
3.阿司匹林在制备抑制木糖葡萄球菌生物被膜药物中的用途ZL201510357706.82018.4
4.水杨酸在制备抑制木糖葡萄球菌生物被膜药物中的用途ZL201510357710.42018.8
5.黄连水提物及其单体在抑制猪链球菌或干预猪链球菌生物被膜药物中的用途ZL201410494065.62018.3
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